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Chapter 1: Management of Biosafety, Chapter 2: Design Issues at the Management/Facility Interface, Chapter 3: Primary Biocontainment Devices, Chapter 4: HVAC Issues in Secondary Biocontainment, Chapter 5: Open BSL-2 Laboratories, Chapter 6: Facility Guidelines for BSL-2 and BSL-3 Biological Laboratories, Chapter 7: Design of BSL-3 Laboratories, Chapter 8: Building a Maximum Containment Laboratory, Chapter 9: Designing the BSL-4 Laboratory, Chapter 10: Role of the Class III Cabinet in Achieving BSL-4, Chapter 11: Containment Design Concepts for Extraterrestrial Sample Return, Chapter 12: Biosafety Considerations for Design of Large-Scale Facilities, Chapter 13: Small Animal Research Facilities and Equipment, Chapter 14: Small Animal Research Facility Management, Chapter 15: Large Animal Research Facilities, Chapter 16: Waste Management Considerations